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A thiol-reactive fluorogenic reagent has been used to detect and quantify thiol-containing amino acids protein and tissue thiols and disulfide linkages ex/em 389/513 nm respectively
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An analytical reference standard categorized as a precursor in the synthesis of fentanyl-related compounds intended for research and forensic applications
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The lyophilized carp Vtg may be used as a positive control in immunoblotting. Freshly reconstituted Vtg may also be used as a standard in a quantitative ELISA. This product contains bovine serum albumin which will appear as a strong protein band in acrylamide gels.
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A GCGR GLP-1R and GIP receptor agonist induces cAMP accumulation in HEK293 cells expressing the human GCGR GLP-1R or GIP receptor (EC50s 5.79 0.775 and 0.0643 nM respectively) decreases plasma glucose levels in an intraperitoneal glucose tolerance test in mice from 0.1-30 nmol/kg decreases body weight calorie intake fat mass and lean mass in a mouse model of diet-induced obesity acute administration delays gastric emptying and chronic administration for 10 days decreases food intake and body weight in mice
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A disulfide bond-containing ionizable cationic lipid has been used in the generation of LNPs for plasmid delivery in vitro and in vivo LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP increase RRSP levels and decrease Ras levels in and reduce the viability of HeLa cancer cells LNPs containing PPPDA-O16B and encapsulating plasmids encoding RRSP selectively localize to tumors over the heart liver spleen lungs and kidneys as well as decrease tumor volume without reducing body weight in an HCT116 colorectal cancer mouse xenograft model
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